Before marrying Maduro, Flores served as president of the National Assembly, making her a central power broker in a country of about 31 million people.
Rodríguez, who is also the country's finance and oil minister, condemned Maduro's arrest as "an atrocity that violates international law" and demanded his "immediate release."
Wearing a Nike sweatsuit, he is seen standing aboard the U.S. Navy's Iwo Jima, en route to New York, where he is expected to face prosecution on narco-terrorism charges.
The United States recognized González as Venezuela's rightful leader after he defeated Maduro by a margin of more than two to one in the 2024 election.
Trump said that the Maduros were taken aboard the USS Iwo Jima, an assault ship, and later flown to New York City, where he appeared in court along with his wife.
A spokesperson for the San Francisco Police Department said investigators are now asking anyone with information about her sudden death to come forward and contact the department.
According to Karen Johannsen's social media, she had been living in St. John's, Antigua and Barbuda, where she often promoted her horseback riding tours along the beach.
Also in attendance were the president's eldest sons, Donald Trump Jr. and Eric Trump, along with his daughter-in-law, Lara Trump, adding to the star-studded feel of the evening.