Weight in First Years of Life Can Impact Lung Health in Later Childhood, Finds Study

The authors of the research analyzed the relationship between the BMI trajectory and the lung function

A study published in the European Respiratory Journal has found that the trajectory of Body mass index (BMI) in the first few years of life may be linked with the function of the lungs in later childhood.

Judith Garcia-Aymerich, co-coordinator of the study, said, "Since weight gain is affected by modifiable factors, public health interventions in early childhood that promote healthy lifestyles--for example, healthy eating and physical activity--can help improve lung function and reduce respiratory morbidity in adulthood."

Differing Weight Trajectories

Representational Picture

Early childhood is a key period for lung function development. Previous studies have found an association between weight in the first years of life and lung health in infancy and childhood. "These studies had certain limitations in terms of defining weight gain," explained Gabriela P. Peralta, a researcher at ISGlobal and lead author of the study. "Most of them only considered the difference in weight between two points in time and did not take the overall trajectory into account. That's why we decided to carry out this new study."

The study used data on more than 1,200 children living in three areas of Spain--Sabadell, Valencia and Gipuzkoa--who were enrolled in the birth cohort of the INMA Environment and Childhood Project. "First, we determined the children's BMI trajectory from birth to age four years and classified them in five categories. The trajectories differed in terms of weight at birth (which could be lower, average or higher) and speed of BMI gain (which could be slower or accelerated)," explained Peralta.

BMI and Lung Function

BMI is an indicator based on the weight in relation to height that is frequently used to classify overweight and obesity. The authors then analyzed the relationship between BMI trajectory and lung function, which was measured by spirometry at age seven years. Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1) and FEV1/FVC ratio were measured.

The findings showed that children with accelerated BMI gain before age four years, regardless of weight at birth, had higher lung function at age seven years but also airflow limitation, which indicates difficulty expelling air from the lungs. In contrast, children with lower weight at birth and slower BMI gain in early childhood had lower lung function at age seven years.

Maribel Casas, a researcher at ISGlobal and co-coordinator of the study, commented: "Our findings have important implications for research and public health." She added: "This study shows that BMI trajectories in early childhood are a useful tool for identifying growth patterns associated with poor respiratory health." Garcia-Aymerich added, "Public health strategies aimed at reducing respiratory health problems may need to focus on early weight gain."

(With inputs from agencies)