Early screening based on family history effective in detecting colorectal cancer, say researchers

For the study, information about individuals 40 to 49 years of age from the Colon Cancer Family Registry from 1998 to 2007

Detection of colorectal cancer can be benefitted through the employment of screening that is based on family history, say researchers from the University of California San Diego.

Published in the journal Cancer, the study pointed out that the rates of colorectal cancer in many countries is on the rise among adults under the age of 50.

Family history could have improved diagnosis

In an analysis that included information on adults diagnosed with colorectal cancer between 40 and 49 years of age, almost all patients could have been diagnosed earlier if they had been screened according to current family history-based screening guidelines.

"Our findings suggest that using family history-based criteria to identify individuals for earlier screening is justified and has promise for helping to identify individuals at risk for young-onset colorectal cancer," said study researcher Samir Gupta from the University of California San Diego in the US. To identify those at risk, current guidelines recommend early screening for colorectal cancer among individuals with a family history of the disease.

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For example, for individuals with a first-degree relative with colorectal cancer, several medical societies recommend initiating screening at 40 years of age or 10 years prior to the age at diagnosis of the youngest relative diagnosed with colorectal cancer.

Family history crucial in findings

To estimate the potential impact of family history-based guidelines for screening, the research team examined information on individuals 40 to 49 years of age - 2,473 with colorectal cancer and 772 without - in the Colon Cancer Family Registry from 1998 to 2007.

The Colon Cancer Family Registry contains information and specimens contributed by more than 15,000 families around the world and across the spectrum of risk for colorectal cancer. The investigators found that 25 percent of individuals with colorectal cancer and 10 percent of those without cancer met the criteria for family history-based early screening.

Almost all (98.4 percent) patients with colorectal cancer who met these criteria should have been screened at a younger age than when their cancer was diagnosed. Therefore, they could have had their cancer diagnosed earlier, or possibly even prevented if earlier screening had been implemented based on family history-based guidelines, the researchers said.

(With inputs from agencies)