China's Inhalable Covid Vaccine as Booster Shot May Boost Antibodies 300-Fold

An inhalable Covid-19 vaccine developed by China's CanSino Biologics has shown an increase of 250- to 300-fold in neutralising antibody levels as a booster shot, the media reported.

As per the latest lab studies by the Chinese drugmaker, the aerosolised inhaled adenovirus Type-5 vector-based Covid-19 vaccine (Ad5-nCoV), taken after completing two doses of inactivated vaccine shots for half a year, is proven to be safe and significantly more immunogenic than taking an inactivated vaccine as a booster, as reported by the Global Times.

Neutralising Antibodies

In contrast, taking an inactivated vaccine as a booster after two inactivated vaccine shots, increases the neutralising antibodies by only 30 times, it added. The study suggests a heterologous (mix-match vaccine regimen) prime-boost regimen increases the breadth, intensity, and duration of the immune response, more than a homogeneous (same vaccine regimen) booster shot, the report said.

 3rd COVID-19 shot
FDA is planning to amend clearances as soon as Thursday for Moderna and Pfizer Covid-19 vaccines to allow extra doses for people with compromised immune systems Twitter

Zhu Tao, CanSinoBIO co-founder, and chief scientific officer cited a previous study conducted in Turkey whose data showed a booster dose of the mRNA vaccine widely used in Western countries for people administered along with two inactivated doses can increase the neutralising antibodies by about 25 times as compared with a booster dose of the inactivated vaccine again.

A similar clinical trial was conducted by US researchers on a heterologous booster shot regimen with three approved vaccines; one adenovirus-based vaccine by Johnson & Johnson and two mRNA vaccines by Moderna and Pfizer. The results showed that a heterologous regimen enhances immunity.

Vaccine Covid-19 Coronavirus
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Homologous boosters increased neutralising antibody titers 4.2- to 20-fold whereas heterologous boosters increased titers 6.2- to 76-fold, said the research report published recently on pre-print server medRvix, meaning it is not yet peer-reviewed.

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